Looks like the computing requirements to simulate this cirecuit in real time are too much for your CPU. The simulation should proceed, but at a slower speed.
I see some issues with the circuit:
Using U1:C and U1: D with linear feedback is a technique sometimes seen but this technique uses the 4069 out of specs in an anlalog way. This may cause issues with the simulation, but honestly I don't know how Proteus handles this.
Pin 5 of the NE555 typically requires a 100 nF buffer capacitor to ground. The modern CMOS versions are more tolerant. Again, I don't know how Proteus handles this. But adding the capacitor won't hurt.
What's the use of D13? There's no power source to feed back into the battery. This diode can as well be removed.
The clock input of U2 is permanently at ground potential:
Turning on Q2 doesn'T change that. I think you want to connect the clock input to the collector of Q2, not the emitter?